N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid
CAS: 162558-25-0
Molecular Formula: C23H26N2O6
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid - Names and Identifiers
| Name | N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid |
| Synonyms | Fmoc-Dap(Boc) FMOC-L-DAP(BOC) FMOC-DAP(BOC)-OH Fmoc-Dap(Boc)-OH FMOC-DPR(BOC)-OH Fmoc-Dpr(Boc)-OH FMOC-DAPA(BOC)-OH FMOC-L-DPA(BOC)-OH FMOC-L-2,3-DIAMINOPROPIONIC ACID(BOC) Fmoc-L-2,3-Diaminopropionic acid(Boc) FMOC-L-2,3-DIAMINOPROPANOIC ACID(BOC) N-Fmoc-N'-Boc-L-2,3-Diaminopropionic acid FMOC-ALPHA,BETA-DIAMINOPROPIONIC ACID(BOC)-OH N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid 3-[(tert-butoxycarbonyl)amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]alanine 3-[(tert-butoxycarbonyl)amino]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-alanine |
| CAS | 162558-25-0 |
| EINECS | 2017-001-1 |
| InChI | InChI=1/C23H26N2O6/c1-23(2,3)31-21(28)24-12-19(20(26)27)25-22(29)30-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,25,29)(H,26,27)/t19-/m1/s1 |
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid - Physico-chemical Properties
| Molecular Formula | C23H26N2O6 |
| Molar Mass | 426.46 |
| Density | 1.263±0.06 g/cm3(Predicted) |
| Melting Point | 131-139 .°C |
| Boling Point | 652.5±55.0 °C(Predicted) |
| Flash Point | 348.4°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 6.45E-18mmHg at 25°C |
| Appearance | White powder |
| Color | White to Almost white |
| BRN | 7057792 |
| pKa | 3.58±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.58 |
| MDL | MFCD00235896 |
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 2924 29 70 |
| Hazard Class | IRRITANT |
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid - Introduction
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid is an organic compound with the following properties:
-Appearance: Usually a white solid.
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF), dichloromethane and acetonitrile.
-Molecular structure: Its molecular formula is C23H27N3O6, and its molecular weight is 441.48g/mol.
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid is often used as a protecting group in organic synthesis and has the following uses:
-Peptide synthesis: In the process of peptide synthesis, it is often used to protect the amino group to prevent unnecessary reactions of other functional groups.
-Drug research: Because of its application in peptide synthesis, it is widely used in drug research and development.
The method for preparing N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid is generally as follows:
1. Dissolve 2,3-diaminopropionic acid in dimethylformamide.
2. Appropriate amounts of N-bis (9-fluoromethylamido) nonyl-n-methylamido (Fmoc-OSu) and BIS (tert-butoxycarbonyl) imine (DICI) were added.
3. Stir the reaction solution at room temperature for 30 minutes.
4. Add chilled ethyl acetate to yield N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid as a solid.
5. Filtration and washing were carried out, and finally dried to obtain the product.
In terms of safety information, N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid should pay attention to the following:
-Wear appropriate personal protective equipment such as lab gloves, goggles and protective clothing during operation.
-Avoid inhaling dust or gas, and operate in a well-ventilated place.
-Avoid contact with oxidizing agents, strong acids or strong bases during storage.
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
Please note that when using and handling chemicals, you should strictly abide by relevant laboratory safety regulations and operate in a suitable environment.
-Appearance: Usually a white solid.
-Solubility: Soluble in organic solvents such as dimethylformamide (DMF), dichloromethane and acetonitrile.
-Molecular structure: Its molecular formula is C23H27N3O6, and its molecular weight is 441.48g/mol.
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid is often used as a protecting group in organic synthesis and has the following uses:
-Peptide synthesis: In the process of peptide synthesis, it is often used to protect the amino group to prevent unnecessary reactions of other functional groups.
-Drug research: Because of its application in peptide synthesis, it is widely used in drug research and development.
The method for preparing N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid is generally as follows:
1. Dissolve 2,3-diaminopropionic acid in dimethylformamide.
2. Appropriate amounts of N-bis (9-fluoromethylamido) nonyl-n-methylamido (Fmoc-OSu) and BIS (tert-butoxycarbonyl) imine (DICI) were added.
3. Stir the reaction solution at room temperature for 30 minutes.
4. Add chilled ethyl acetate to yield N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid as a solid.
5. Filtration and washing were carried out, and finally dried to obtain the product.
In terms of safety information, N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid should pay attention to the following:
-Wear appropriate personal protective equipment such as lab gloves, goggles and protective clothing during operation.
-Avoid inhaling dust or gas, and operate in a well-ventilated place.
-Avoid contact with oxidizing agents, strong acids or strong bases during storage.
-In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help.
Please note that when using and handling chemicals, you should strictly abide by relevant laboratory safety regulations and operate in a suitable environment.
Last Update：2024-04-09 20:11:46
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View History
N(alpha)-fmoc-N(beta)-boc-L-2,3-diamino-propionic acid
1,3-Dioxolane, 2-[(4R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]pentyl]-
4-氯-ALPHA-甲基苯乙腈
NELFINAVIR MESYLATE
Cyproterone 17alpha-acetate
N,N',N'',N'''-[carbonylbis(nitrilodiethylene)]tetrastearamide diacetate
Pyridine, 2-chloro-4-iodo-6-(trifluoromethyl)-
2-甲氨基吡啶-4-氟
1-(3-二甲基胺丙基)-3-乙基碳二亚胺
[LEU15]-GASTRIN I
1,3-Dioxolane, 2-[(4R)-4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]pentyl]-
4-氯-ALPHA-甲基苯乙腈
NELFINAVIR MESYLATE
Cyproterone 17alpha-acetate
N,N',N'',N'''-[carbonylbis(nitrilodiethylene)]tetrastearamide diacetate
Pyridine, 2-chloro-4-iodo-6-(trifluoromethyl)-
2-甲氨基吡啶-4-氟
1-(3-二甲基胺丙基)-3-乙基碳二亚胺
[LEU15]-GASTRIN I